The Pufferfish is part of the Tetraodontidae family, together with balloonfish, blowfish, bubblefish, globefish, swellfish, toadfish, toadies, honey toads, and sea squab. It is believed to be the second–most poisonous vertebrate in the world, after the Golden Poison Frog, and has toxic internal organs and skin. The meat f this species of fish is considered a delicacy in Japan, Korea and China, and it can be safely prepared by killing and gutting the fish while it is fresh. The Pufferfish poisoning happens when it is incorrectly prepared and can cause intoxication, light-headedness, and numbness of the lips or even death. The substance that is causing the poisoning is called tetrodotoxin and it induces dizziness and vomiting, numbness and prickling over the body, rapid heart rate, decreased blood pressure, and muscle paralysis.

The consumption can even induce coma for a few days, but neural activity in the brain and from the eyes and ears are generally intact, so many people that experienced Pufferfish poisoning claim that they heard and saw everything around them for that period of time. These fish are usually consumed by mistake and many of the death related to the poisoning happen because the fish is not properly cooked., but the effects can be reversed by gastric lavage and activated charcoal.

Heroin is a semi-synthetic opioid drug synthesized from morphine, which is extracted from opium poppy and is used both as analgesic and a recreational drug. But if it is frequently consumed it is associated with tolerance and physical dependence, which may develop into addiction. Heroin is subject to the Single Convention on Narcotic Drugs and it is illegal to manufacture, possess, or sell it without owning a license.

It is available on prescription for certain patients, but it is associated with lots of risks: the risk of contacting diseases that can be transmitted by means of infected syringes, like HIV and hepatitis, the risk of being poisoned by the substances that pure heroin is diluted with, chronic constipation, addiction, physical dependence or decreased kidney function. Another risk associated with the consumption of heroin is dying from overdose.

Hemlock is a deadly poisonous plant from the family of Apiaceae, native to Europe, the Mediterranean region and southern Africa. Hemlock contains a toxic substance called coniine, which has a chemical structure similar to nicotine. It is a neurotoxin, which harms the central nervous system, and its consumption can result in respiratory collapse and death by blocking the neuromuscular junction and eventually results in muscular paralysis of the respiratory muscles which causes death because of lack of oxygen to the heart and brain.

Hemlock is a poison commonly used in the ancient Greece to poison condemned prisoners, and this is the poison which is supposed to have killed Socrates. The plant is also used for medical purposes, as a sedative and for its antispasmodic properties, and in some areas of the world as a homeopathic treatment.